Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

In June, Jefferson signed a record-setting deal with Minnesota. The four-year, $140 million contract extension made Jefferson ...

San Francisco 49ers star running back Christian McCaffrey could be out for six weeks or more due to his calf soreness and ...

Minnesota Vikings vs. San Francisco 49ers starts at 1 p.m. ET on Sept. 15. This fixture takes place at the U.S. Bank Stadium.

The 49ers' eighth straight loss in Minnesota exposes weaknesses and serves as a reality check for the team's performance.

San Francisco 49ers running back Christian McCaffrey is going to be out for at least the next four games. Per ESPN's Adam ...

The San Francisco 49ers went into the offseason with only one quarterback under contract. Last season Sam Darnold held down ...

The 49ers, who were 2 for 10 on third down conversions and 1 for 3 on fourth down attempts, went for it on fourth-and-goal from the 2 early in the second quarter. Brock Purdy's pass for Jauan Jennings ...

Christian McCaffrey's calf and Achilles injuries continues to linger as the team considers placing him on injured reserve.

The San Francisco 49ers are dealing with another notable injury. The 49ers, who recently put All-Pro running back Christian ...

A San Francisco 49ers star defender did not mince his words when talking about the New York Jets after their Week 1 matchup.

Although the Rams-49ers rivalry has been decidedly tilted in San Francisco's direction in recent years, the games have still been must-see spectacles.