The actress, who stars alongside Demi Moore in the body horror film, says it took "probably a year" for her skin to recover.

The actress recalled what it was like working with prosthetics for her role in the body horror film, which also stars Demi Moore.

Adhesive materials, artificial skin, and layers of heavy makeup used to create these effects can often clog pores

During a recent appearance on the Happy Sad Confused podcast, Margaret Qualley revealed that the prosthetics she wore in "The Substance" "f--ked up" her skin, saying that it took "a year" for her skin to fully recover from the acne.

"It took me probably, like, a year to recover physically from all of it," she told a podcast about the prosthetics used in the film.

Qualley stars in the film opposite Demi Moore, who plays an aging film star Elisabeth Sparkle. Sparkle takes the "substance" in order to transform into Sue (Qualley) but there's a catch: the pair must switch back every seven days. If they don't, Sue will begin deteriorating (and, it turns out, so will Sparkle).